Ribosomes in Cell Nucleus
نویسندگان
چکیده
منابع مشابه
Diffusion-based transport of nascent ribosomes in the nucleus.
Although the complex process of ribosome assembly in the nucleolus is beginning to be understood, little is known about how the ribosomal subunits move from the nucleolus to the nuclear membrane for transport to the cytoplasm. We show here that large ribosomal subunits move out from the nucleolus and into the nucleoplasm in all directions, with no evidence of concentrated movement along directe...
متن کاملVisualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleus.
In eukaryotes the 40S and 60S ribosomal subunits are assembled in the nucleolus, but there appear to be mechanisms preventing mRNA binding, 80S formation, and initiation of translation in the nucleus. To visualize association between ribosomal subunits, we tagged pairs of Drosophila ribosomal proteins (RPs) located in different subunits with mutually complementing halves of fluorescent proteins...
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A single mammalian cell includes an order of 10(4)-10(5) mRNA molecules and as many as 10(5)-10(6) ribosomes. Large-scale simultaneous mRNA translation induces correlations between the mRNA molecules, as they all compete for the finite pool of available ribosomes. This has important implications for the cell's functioning and evolution. Developing a better understanding of the intricate correla...
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The brain stem auditory system of the chick is an advantageous model for examining changes that occur as a result of deafness. Elimination of acoustic input through cochlear ablation results in the eventual death of approximately 30% of neurons in the chick cochlear nucleus, nucleus magnocellularis (NM). One early change following deafness is an alteration in NM ribosomes, evidenced both by a d...
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8 Magasanik, B., in Cellular Regulatory Mechanisms, Cold Spring Harbor Symposia on Quantitative Biology, vol. 26 (1961), p. 249. 9Jones, M., L. Spector, and F. Lipmann, J. Am. Chem. Soc., 77, 819 (1955). 10 Gerhart, J. C., and A. B. Pardee, J. Biol. Chem., 237, 891 (1962). "Ratner, S., W. P. Anslow, and B. Petrack, J. Biol. Chem., 204, 115 (1953). "2In Methods in Enzymology, ed. S. P. Colowick ...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1965
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.5.199